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Peptide record

TPDB71972

Neurotoxin standard
1413 amino acids
Basic Information
3D PDB MODEL
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TPDB71972
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 1413-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
VSIFIFHFSANILVRNSEMKGKRVISKREMSKADQCTFLSYQSVAYGTLGDVAGDVSSIEGADLVATPIAAGGHLAKGATDAAMIAMDCSSIPFDEIKQQLNQRFNEVDKKLQKGAEALENVTELAEKTYSSVEKMRVEMREGFNHVIATIENANTKQIITGINQIIQYFNDERENINNRQKEDYVAKLQEPASGNFLLYLRKSRTSEDGSLHSLLFKIINQELAIPNNAADNNAIRALFALFYGTQTFISIMFYLVKQYSYLADYHYQNGNLAEFNSNFDHMKTVFQDFKFTLIGINTSNSKPLVNTVLSIIEDVKNKRFIRNLRSNLYQKIIKSTKSLLDLREKITKMDLPIIEDTPKSSVLINFREKSSSVPRIETPILKWTPGTVVKYAIQYEQDGKYSKISKWSNPITVQRLANPYITIDKDRRNRLVFRQFGNEKPELISILDSSQNEFRDIHRDLYNAAQMPYKETALGICRKLIDSGAQVGASFEMGRKSIHASATAGNDDVARLLLAKNNGLLNVPDKNGYTPLHIASERKNNDFVKFLLEKGADVNVRTFANELTPLHLAARQDFTIIVKTLMEKRGIDVNAKERAGFTPLHLSITSNSRAARTLINETPAGINIKSNSGLTPLHLAVLQNNLSAAKVLVKSNKKVKLNEMDNNGMTPLHYASMLGNLEFVKYFTSEQGIDVNAKTKVKNWTPLHLAILFKKFDVAQSLLQVRNIDISTRADQAITPLHLAAATGNSQIVKTILNSGAVVDQETANGFTALHLAIMNPNTETPQFLIAKGANINAKTNDGSTPLHFAAALGKTNIFQLLMDKGANIKAENLINQMPIHEAVVNGHLAIVKMLIEQDSSLMNAKNMRDEYPFYLAAEKRYKDVFNYLESKGADVNEKNNDGNTLLHLFSINGEVEVVQFLIQNGADFRLRNKERKSFFDLAVEFGHAGIVGYAIEENKVDLQEPYRGKTILYHAICDSVKYDRIEVVRYFVETLNEDQCSPLQEAAAYAHLDLVKYFVQERGINPTAFNNDNQVSPLCIAIVGAPCGFVKSCDTPERLDVVEYLVDKTPDINKECDTQQSTPVSSAVYGNKVSILNYLIRNGADPNKKVRGDPPLFIAAMIGQYDIVKSLVEQHKIDVNTRNKEQFTPLHAAASNDHIDVVKYLIQKGADVNAKGDENLKPIDLAGEKSKAYLRSLGRRFFRNESPSKSFEIDKFNAIMPEVSMSGKVSHDSNFIQHISSGTRSKSNFNSAKNKMYAENSHVRSIDVNGALLLLDFMVRVFSNRKMNYAASISGIKSRSNSEAQAEALILTERFEHLLNALIADQSIDSLDFSNVHSRIYKAIINGNPNGISEMLCSYAKEYSELDPEKIEKLLQEFETLTFTKSSEIQINEKFSHALFETCGLNRPTNVLQIK
Physicochemical Analysis
C7031H11189N1943O2127S39
L
158223.26
8.24
200
162
581
+9
328.60
-0.315
91.42
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
82685
52.26
400
Residue Composition
number
117
A
61
R
118
N
76
D
11
C
86
E
55
Q
68
G
32
H
109
I
129
L
107
K
28
M
66
F
46
P
104
S
68
T
3
W
44
Y
85
V
Amino Acid Distribution
A: 117 R: 61 N: 118 D: 76 C: 11 E: 86 Q: 55 G: 68 H: 32 I: 109 L: 129 K: 107 M: 28 F: 66 P: 46 S: 104 T: 68 W: 3 Y: 44 V: 85
Chemical Descriptors
1413
C7031H11189N1943O2127S39
158223.26
8.24
+9
328.60
-0.315
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Crustacean-selective presynaptic neurotoxin that induces neurotransmitter exocytosis. May bind to crustacean neurexin-1 homolog, adhesion G protein-coupled receptor L1 homolog, and receptor-type tyrosine-protein phosphatase S homolog, and induces neurotransmitter exocytosis both by forming tetrameric pores in membranes and signaling via G protein-coupled receptor (By similarity) (PubMed:34845192). This recombinant protein form channels in artificial membrane bilayers, that are stabilized by calcium ions and allow calcium flux at negative membrane potentials (PubMed:34845192). {ECO:0000250|UniProtKB:P23631, ECO:0000269|PubMed:34845192}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus)
Neurotoxin Presynaptic neurotoxin
Crustacean-selective presynaptic neurotoxin that induces neurotransmitter exocytosis. May bind to crustacean neurexin-1 homolog, adhesion G protein-coupled receptor L1 homolog, and receptor-type tyrosine-protein phosphatase S homolog, and induces neurotransmitter exocytosis both by forming tetrameric pores in membranes and signaling via G protein-coupled receptor (By similarity) (PubMed:34845192).
Alpha-latrocrustotoxin-Lt1a (Alpha-LCT-Lt1a) (Alpha-latrocrustotoxin) (Alpha-LCT) (Crusta1)
spider
Cationic peptide 01 (latrotoxin) family, 01 (alpha-latrocrustotoxin) subfamily
Evidence at protein level
3D-structure ANK repeat Cleavage on pair of basic residues Exocytosis Membrane Neurotoxin Presynaptic neurotoxin Repeat Secreted Target cell membrane Target membrane Toxin Transmembrane
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10234443}.
Additional Detail Fields 7 fields
3D-structure ANK repeat Cleavage on pair of basic residues Exocytosis Membrane Neurotoxin Presynaptic neurotoxin Repeat Secreted Target cell membrane Target membrane Toxin Transmembrane
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Cationic peptide 01 (latrotoxin) family, 01 (alpha-latrocrustotoxin) subfamily
Alpha-latrocrustotoxin-Lt1a (Alpha-LCT-Lt1a) (Alpha-latrocrustotoxin) (Alpha-LCT) (Crusta1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10234443}.
spider