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Peptide record

TPDB71964

Neurotoxin standard
239 amino acids
Basic Information
3D PDB MODEL
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TPDB71964
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 239-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSLIIVLVISVLSADAVLSMDNELYLNLEPSQRSSWPVARAVRMQFSKRSEGGRESRKMQGCQILESLNDIAREALRTPRHTTKRISKDEMEFFEGRCLSVGESERTVLGTKWCGAGNEAANYSDLGYFNNVDRCCREHDHCDNIPAGETKYGLKNEGTYTMMNCKCEKAFDKCLSDISGYFTRKAVSAVKFTYFTLYGNGCYNVKCENGRSPSNECPNGVAEYTGETGLGAKVINFGK
Physicochemical Analysis
C1147H1810N330O363S19
G
26640.12
7.34
34
30
83
+1
58.12
-0.475
65.69
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
26650
100.04
75
Residue Composition
number
15
A
16
R
16
N
10
D
12
C
20
E
4
Q
21
G
3
H
9
I
17
L
15
K
7
M
9
F
6
P
20
S
13
T
2
W
10
Y
14
V
Amino Acid Distribution
A: 15 R: 16 N: 16 D: 10 C: 12 E: 20 Q: 4 G: 21 H: 3 I: 9 L: 17 K: 15 M: 7 F: 9 P: 6 S: 20 T: 13 W: 2 Y: 10 V: 14
Chemical Descriptors
239
C1147H1810N330O363S19
26640.12
7.34
+1
58.12
-0.475
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxic phospholipase A2, which may catalyze the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Inhibits both skeletal (RYR1) and cardiac (RYR2) ryanodine receptors (calcium release channels). Probably blocks ryanodine receptors by generating a lipid product (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav) ryanodine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hoffmannihadrurus gertschi (Scorpion) (Hadrurus gertschi)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin
Toxic phospholipase A2, which may catalyze the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Inhibits both skeletal (RYR1) and cardiac (RYR2) ryanodine receptors (calcium release channels).
Phospholipase A2 (HgPLA2) (EC 3.1.1.4) (Group III heterodimeric phospholipase A2) (Phosphatidylcholine 2-acylhydrolase) [Cleaved into: Phospholipase A2 large subunit Phospholipase A2 small subunit]
scorpion
Phospholipase A2 family, Group III subfamily
Evidence at transcript level
Calcium Calcium channel impairing toxin Disulfide bond Hydrolase Ion channel impairing toxin Lipid degradation Lipid metabolism Metal-binding Neurotoxin Ryanodine-sensitive calcium-release channel impairing toxin Secreted Signal Toxin Zymogen
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium Calcium channel impairing toxin Disulfide bond Hydrolase Ion channel impairing toxin Lipid degradation Lipid metabolism Metal-binding Neurotoxin Ryanodine-sensitive calcium-release channel impairing toxin Secreted Signal Toxin Zymogen
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin
Evidence at transcript level
Phospholipase A2 family, Group III subfamily
Phospholipase A2 (HgPLA2) (EC 3.1.1.4) (Group III heterodimeric phospholipase A2) (Phosphatidylcholine 2-acylhydrolase) [Cleaved into: Phospholipase A2 large subunit Phospholipase A2 small subunit]
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion