Back to search

Peptide record

TPDB71956

Neurotoxin standard
67 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB71956
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 67-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MNLKLALVLLLTVINVGMLPGATSNGNIKTDIKCYRNSHCNFHCEKSYYCQGSKCVRKRCNCYNCPL
Physicochemical Analysis
C325H529N95O92S10
W
NCL
7559.96
8.94
11
2
24
+7
6.62
-0.093
84.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6460
85.45
28
Residue Composition
number
2
A
3
R
8
N
1
D
8
C
1
E
1
Q
4
G
2
H
3
I
8
L
6
K
2
M
1
F
2
P
4
S
3
T
0
W
4
Y
4
V
Amino Acid Distribution
A: 2 R: 3 N: 8 D: 1 C: 8 E: 1 Q: 1 G: 4 H: 2 I: 3 L: 8 K: 6 M: 2 F: 1 P: 2 S: 4 T: 3 W: 0 Y: 4 V: 4
Chemical Descriptors
67
C325H529N95O92S10
7559.96
8.94
+7
6.62
-0.093
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium channels. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Opisthacanthus cayaporum (South American scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Inhibits voltage-gated potassium channels..
Potassium channel toxin alpha-KTx 6.16 (OcyC12)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at transcript level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Potassium channel toxin alpha-KTx 6.16 (OcyC12)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion