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Peptide record

TPDB71950

Neurotoxin standard
79 amino acids
Basic Information
3D PDB MODEL
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TPDB71950
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 79-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKKTFCFILILVCIVLKSVNAEEEDNFEESSLEMETARCASKNERCGNALYGTKGPGCCNGKCICRTVPRKGVNSCRCM
Physicochemical Analysis
C365H605N107O114S13
QHW
C
8733.25
7.95
12
9
25
+3
21.27
-0.148
67.85
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2115
24.22
26
Residue Composition
number
4
A
5
R
6
N
1
D
10
C
8
E
0
Q
6
G
0
H
4
I
5
L
7
K
3
M
3
F
2
P
5
S
4
T
0
W
1
Y
5
V
Amino Acid Distribution
A: 4 R: 5 N: 6 D: 1 C: 10 E: 8 Q: 0 G: 6 H: 0 I: 4 L: 5 K: 7 M: 3 F: 3 P: 2 S: 5 T: 4 W: 0 Y: 1 V: 5
Chemical Descriptors
79
C365H605N107O114S13
8733.25
7.95
+3
21.27
-0.148
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insect-specific toxin that probably acts as an inhibitor of presynaptic insect calcium channels, presumably Cav2 subtype. In vivo, induces immediate paralysis on insects, followed by death when high doses are injected. {ECO:0000269|PubMed:26611444}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tibellus oblongus (Oblong running crab spider)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Insect-specific toxin that probably acts as an inhibitor of presynaptic insect calcium channels, presumably Cav2 subtype. In vivo, induces immediate paralysis on insects, followed by death when high doses are injected..
Omega-phylotoxin-To1a (Omega-PHTX-To1a) (Omega-Tbo-IT1)
spider
Evidence at protein level
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:26611444}.
Additional Detail Fields 6 fields
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Omega-phylotoxin-To1a (Omega-PHTX-To1a) (Omega-Tbo-IT1)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:26611444}.
spider