Back to search

Peptide record

TPDB71938

Neurotoxin standard
99 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB71938
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 99-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MIASMKPWPLVMVAALCILFCLGTLVDAYPTKPESPGPDATPEELAEYMTKIRQYINLVTRQRYGKRSSPETLMSELIFGENSNSDHSSRSRFDDSYMW
Physicochemical Analysis
C500H778N130O151S8
S
11282.94
5.11
11
12
40
-2
17.42
-0.322
72.93
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
18575
164.63
29
Residue Composition
number
6
A
6
R
3
N
5
D
2
C
7
E
2
Q
4
G
1
H
5
I
9
L
4
K
6
M
3
F
8
P
11
S
6
T
2
W
5
Y
4
V
Amino Acid Distribution
A: 6 R: 6 N: 3 D: 5 C: 2 E: 7 Q: 2 G: 4 H: 1 I: 5 L: 9 K: 4 M: 6 F: 3 P: 8 S: 11 T: 6 W: 2 Y: 5 V: 4
Chemical Descriptors
99
C500H778N130O151S8
11282.94
5.11
-2
17.42
-0.322
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Shows a potent unique triphasic action, rapid biphasic hypertension followed by prolonged hypotension. {ECO:0000269|PubMed:20631207}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Varanus eremius (Rusty desert monitor)
Neurotoxin
Shows a potent unique triphasic action, rapid biphasic hypertension followed by prolonged hypotension..
Goannatyrotoxin-Vere1 (Venom peptide YY-like)
other
NPY family
Evidence at transcript level
Amidation Cleavage on pair of basic residues Hypotensive agent Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the mandibular venom gland.
Additional Detail Fields 7 fields
Amidation Cleavage on pair of basic residues Hypotensive agent Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at transcript level
NPY family
Goannatyrotoxin-Vere1 (Venom peptide YY-like)
TISSUE SPECIFICITY: Expressed by the mandibular venom gland.
other