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Peptide record

TPDB71923

Neurotoxin standard
83 amino acids
Basic Information
3D PDB MODEL
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TPDB71923
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 83-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
KEGYPMGRDGCKISCVINNNFCKVECQAKWRQSDGYCYFWGLSCYCTIYQKTPRFGILAPINVEDNVTVTQCLGHLINVMYSH
Physicochemical Analysis
C421H639N113O120S10
C
9523.99
7.84
10
6
31
+2
7.26
-0.186
70.36
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
20440
214.62
32
Residue Composition
number
2
A
3
R
6
N
3
D
8
C
3
E
4
Q
7
G
2
H
6
I
4
L
5
K
2
M
3
F
3
P
4
S
4
T
2
W
6
Y
6
V
Amino Acid Distribution
A: 2 R: 3 N: 6 D: 3 C: 8 E: 3 Q: 4 G: 7 H: 2 I: 6 L: 4 K: 5 M: 2 F: 3 P: 3 S: 4 T: 4 W: 2 Y: 6 V: 6
Chemical Descriptors
83
C421H639N113O120S10
9523.99
7.84
+2
7.26
-0.186
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Rhopalurus junceus (Caribbean blue scorpion) (Heteroctenus junceus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing..
Putative beta-neurotoxin RjAa32
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21605585}.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Putative beta-neurotoxin RjAa32
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21605585}.
scorpion