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Peptide record

TPDB71920

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB71920
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
iDPPIV
Cardiometabolic peptides
iDPPIV Peptipedia
standard
No
A 3-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.
Sequence
YPY
Physicochemical Analysis
C23H27N3O6
ARNDCEQGHILKMFSTWV
Y
441.48
5.88
0
0
2
-0
-1.43
-1.400
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
675.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
3
C23H27N3O6
441.48
5.88
-0
-1.43
-1.400
441.4759
441.1893
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
iDPPIV
243.70 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., FitzGerald R. J.
Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chemistry 145, 845-852, 2014
2014
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C23H27N3O6/c24-18(12-14-3-7-16(27)8-4-14)22(30)26-11-1-2-20(26)21(29)25-19(23(31)32)13-15-5-9-17(28)10-6-15/h3-10,18-20,27-28H,1-2,11-13,24H2,(H,25,29)(H,31,32)/t18-,19-,20-/m0/s1 InChIKey=VPEFOFYNHBWFNQ-UFYCRDLUSA-N Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9550)
Additional Detail Fields 1 fields
3