TPDB

3D PDB MODEL

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TPDB ID TPDB71918

Peptide_Name

Dipeptidyl peptidase IV inhibitor

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural idppiv peptide sequence curated from iDPPIV, with an available 3D structural model.

Sequence

YPVEPFT

FASTA

>TPDB71918|iDPPIV|length=7
YPVEPFT

Formula C42H57N7O12

Absent Amino Acids ARNDCQGHILKMSW

Common Amino Acids P

Mass 851.95

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 1.06

Hydrophobicity -0.243

Aliphatic Index 41.43

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 174.89

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

2

P

0

S

1

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 1 W: 0 Y: 1 V: 1

Length

7

Formula

C42H57N7O12

Mass

851.95

PI

3.29

Net Charge

-1

Boman Index

1.06

Hydrophobicity

-0.243

Chemical_Mass

851.9394

Monoisotopic_Mass

851.4051

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 175.70 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Du X., Jiang C., Wang S., Jing H., Mo L., Ma C., Wang H.

Title

Preparation, identification, and inhibitory mechanism of dipeptidyl peptidase IV inhibitory peptides from goat milk whey protein. J. Food Sci., 88, 3577–3593, 2023

Year 2023

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)O InChI=1S/C42H57N7O12/c1-23(2)34(46-38(56)32-12-7-19-48(32)40(58)28(43)21-26-13-15-27(51)16-14-26)39(57)44-29(17-18-33(52)53)41(59)49-20-8-11-31(49)37(55)45-30(22-25-9-5-4-6-10-25)36(54)47-35(24(3)50)42(60)61/h4-6,9-10,13-16,23-24,28-32,34-35,50-51H,7-8,11-12,17-22,43H2,1-3H3,(H,44,57)(H,45,55)(H,46,56)(H,47,54)(H,52,53)(H,60,61)/t24-,28+,29+,30+,31+,32+,34+,35+/m1/s1 InChIKey=FZMMLGGZABAZMN-VTWNIBLCSA-N

Number_of_Residues

7