TPDB

3D PDB MODEL

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TPDB ID TPDB71915

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.

Sequence

YPFPGPIPD

FASTA

>TPDB71915|iDPPIV|length=9
YPFPGPIPD

Formula C50H67N9O13

Absent Amino Acids ARNCEQHLKMSTWV

Common Amino Acids P

Mass 1002.13

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 0.66

Hydrophobicity -0.478

Aliphatic Index 43.33

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 148.68

Polar Residues 1

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

1

G

0

H

1

I

0

L

0

K

0

M

1

F

4

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 4 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

9

Formula

C50H67N9O13

Mass

1002.13

PI

3.10

Net Charge

-1

Boman Index

0.66

Hydrophobicity

-0.478

Chemical_Mass

1002.1168

Monoisotopic_Mass

1001.4842

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 670.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Uenishi H, Kabuki T, Seto Y, Serizawa A, Nakajima H

Title

Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from goudatype cheese and its effect on plasma glucose in rats. Int Dairy J (2012) 22:24–30

Year 2012

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(O)=O)C(O)=O InChI=1S/C50H67N9O13/c1-3-29(2)42(49(70)59-24-10-16-39(59)45(66)54-35(50(71)72)27-41(62)63)55-46(67)37-14-7-21-56(37)40(61)28-52-43(64)36-13-8-23-58(36)48(69)34(26-30-11-5-4-6-12-30)53-44(65)38-15-9-22-57(38)47(68)33(51)25-31-17-19-32(60)20-18-31/h4-6,11-12,17-20,29,33-39,42,60H,3,7-10,13-16,21-28,51H2,1-2H3,(H,52,64)(H,53,65)(H,54,66)(H,55,67)(H,62,63)(H,71,72)/t29-,33-,34-,35-,36-,37-,38-,39-,42-/m0/s1 InChIKey=WHUMHCNDCNAHPK-UDZSMLTASA-N

Number_of_Residues

9