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Peptide record

TPDB71906

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB71906
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
iDPPIV
Cardiometabolic peptides
iDPPIV Peptipedia
standard
No
A 3-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.
Sequence
WRP
Physicochemical Analysis
C22H31N7O4
ANDCEQGHILKMFSTYV
RPW
457.53
11.05
1
0
1
+1
-0.59
-2.333
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1202.10
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C22H31N7O4
457.53
11.05
+1
-0.59
-2.333
457.5248
457.2431
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
iDPPIV
780.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ito S., Kawarasaki Y.
Trp-Arg-Xaa tripeptides act as uncompetitive-type inhibitors of human dipeptidyl peptidase IV. Peptides, 54, 166-170, 2014
2014
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C22H31N7O4/c23-15(11-13-12-27-16-6-2-1-5-14(13)16)19(30)28-17(7-3-9-26-22(24)25)20(31)29-10-4-8-18(29)21(32)33/h1-2,5-6,12,15,17-18,27H,3-4,7-11,23H2,(H,28,30)(H,32,33)(H4,24,25,26)/t15-,17-,18-/m0/s1 InChIKey=VIWQOOBRKCGSDK-SZMVWBNQSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides
Additional Detail Fields 1 fields
3