TPDB

3D PDB MODEL

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TPDB ID TPDB71884

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural idppiv peptide sequence curated from iDPPIV, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

VPPFIQPE

FASTA

>TPDB71884|iDPPIV|length=8
VPPFIQPE

Formula C45H67N9O12

Absent Amino Acids ARNDCGHLKMSTWY

Common Amino Acids P

Mass 926.08

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 2.58

Hydrophobicity -0.037

Aliphatic Index 85.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

1

E

1

Q

0

G

0

H

1

I

0

L

0

K

0

M

1

F

3

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

8

Formula

C45H67N9O12

Mass

926.08

PI

3.29

Net Charge

-1

Boman Index

2.58

Hydrophobicity

-0.037

Chemical_Mass

926.0639

Monoisotopic_Mass

925.4893

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 2500.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Uenishi H, Kabuki T, Seto Y, Serizawa A, Nakajima H

Title

Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from goudatype cheese and its effect on plasma glucose in rats. Int Dairy J (2012) 22:24–30

Year 2012

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(O)=O)C(O)=O InChI=1S/C45H67N9O12/c1-5-26(4)37(41(61)48-28(17-19-34(46)55)42(62)52-21-9-14-31(52)39(59)49-29(45(65)66)18-20-35(56)57)51-38(58)30(24-27-12-7-6-8-13-27)50-40(60)32-15-10-22-53(32)43(63)33-16-11-23-54(33)44(64)36(47)25(2)3/h6-8,12-13,25-26,28-33,36-37H,5,9-11,14-24,47H2,1-4H3,(H2,46,55)(H,48,61)(H,49,59)(H,50,60)(H,51,58)(H,56,57)(H,65,66)/t26-,28-,29-,30-,31-,32-,33-,36-,37-/m0/s1 InChIKey=XZFCCNOVLLEABC-VPGCIKRGSA-N

Number_of_Residues

8