TPDB

3D PDB MODEL

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TPDB ID TPDB71882

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP-IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.

Sequence

VPL

FASTA

>TPDB71882|iDPPIV|length=3
VPL

Formula C16H29N3O4

Absent Amino Acids ARNDCEQGHIKMFSTWY

Common Amino Acids LPV

Mass 327.42

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -0.04

Hydrophobicity 2.133

Aliphatic Index 226.67

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

3

Formula

C16H29N3O4

Mass

327.42

PI

6.02

Net Charge

-0

Boman Index

-0.04

Hydrophobicity

2.133

Chemical_Mass

327.4180

Monoisotopic_Mass

327.2151

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 15.80 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Nongonierma A. B., FitzGerald R. J.

Title

An in silico model to predict the potential of dietary proteins as sources of dippetidyl peptidase IV (DPP-IV) inhibitory peptides. Food Chemistry 165 (2014), 489-498.

Year 2014

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C16H29N3O4/c1-9(2)8-11(16(22)23)18-14(20)12-6-5-7-19(12)15(21)13(17)10(3)4/h9-13H,5-8,17H2,1-4H3,(H,18,20)(H,22,23)/t11-,12-,13-/m0/s1 InChIKey: NHXZRXLFOBFMDM-AVGNSLFASA-N Inhibitor of Prolyl oligopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001) according to the BIOPEP-UWM database of bioactive peptides (ID 3166) Peptide stimulating vasoactive substance release according to the BIOPEP-UWM database of bioactive peptides (ID 3350) Inhibitor of Xaa-Pro dipeptidyl-peptidase (EC 3.4.14.11) (MEROPS ID: S15.001) according to the BRENDA database

Number_of_Residues

3