TPDB

3D PDB MODEL

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TPDB ID TPDB71881

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural idppiv peptide sequence curated from iDPPIV, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

VPITPTL

FASTA

>TPDB71881|iDPPIV|length=7
VPITPTL

Formula C35H61N7O10

Absent Amino Acids ARNDCEQGHKMFSWY

Common Amino Acids PT

Mass 739.91

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index 0.38

Hydrophobicity 1.129

Aliphatic Index 152.86

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

1

L

0

K

0

M

0

F

2

P

0

S

2

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 2 W: 0 Y: 0 V: 1

Length

7

Formula

C35H61N7O10

Mass

739.91

PI

6.02

Net Charge

-0

Boman Index

0.38

Hydrophobicity

1.129

Chemical_Mass

739.8973

Monoisotopic_Mass

739.4465

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 1.10 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Uenishi H., Kabuki T., Seto Y., Serizawa A., Nakajima H.

Title

Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats. International Dairy Journal, 2012, 22, 24-30.

Year 2012

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C35H61N7O10/c1-9-19(6)26(38-29(45)23-12-10-14-41(23)33(49)25(36)18(4)5)31(47)40-28(21(8)44)34(50)42-15-11-13-24(42)30(46)39-27(20(7)43)32(48)37-22(35(51)52)16-17(2)3/h17-28,43-44H,9-16,36H2,1-8H3,(H,37,48)(H,38,45)(H,39,46)(H,40,47)(H,51,52)/t19-,20+,21+,22-,23-,24-,25-,26-,27-,28-/m0/s1 InChIKey: LSVSKFOVHVJMBK-WFDLYFBBSA-N

Number_of_Residues

7