TPDB

3D PDB MODEL

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TPDB ID TPDB71880

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural idppiv peptide sequence curated from iDPPIV, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

VPITPT

FASTA

>TPDB71880|iDPPIV|length=6
VPITPT

Formula C29H50N6O9

Absent Amino Acids ARNDCEQGHLKMFSWY

Common Amino Acids PT

Mass 626.75

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index 0.94

Hydrophobicity 0.683

Aliphatic Index 113.33

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

2

P

0

S

2

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 2 W: 0 Y: 0 V: 1

Length

6

Formula

C29H50N6O9

Mass

626.75

PI

6.02

Net Charge

-0

Boman Index

0.94

Hydrophobicity

0.683

Chemical_Mass

626.7401

Monoisotopic_Mass

626.3627

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 130.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Uenishi H., Kabuki T., Seto Y., Serizawa A., Nakajima H.

Title

Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats. Int. Dairy J., 22, 24-30, 2012

Year 2012

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)O InChI=1S/C29H50N6O9/c1-7-15(4)21(31-24(38)18-10-8-12-34(18)27(41)20(30)14(2)3)26(40)32-22(16(5)36)28(42)35-13-9-11-19(35)25(39)33-23(17(6)37)29(43)44/h14-23,36-37H,7-13,30H2,1-6H3,(H,31,38)(H,32,40)(H,33,39)(H,43,44)/t15-,16+,17+,18-,19-,20-,21-,22-,23-/m0/s1 InChIKey=SJZSLGPYAVBLSF-JRJRRAIFSA-N

Number_of_Residues

6