TPDB

3D PDB MODEL

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TPDB ID TPDB71861

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.

Sequence

TQMVDEEIMEKFR

FASTA

>TPDB71861|iDPPIV|length=13
TQMVDEEIMEKFR

Formula C70H114N18O24S2

Absent Amino Acids ANCGHLPSWY

Common Amino Acids E

Mass 1655.90

PI 4.16

Basic Residues 2

Acidic Residues 4

Hydrophobic Residues 5

Net Charge -2

Boman Index 7.98

Hydrophobicity -0.869

Aliphatic Index 52.31

Half Life

Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

1

R

0

N

1

D

0

C

3

E

1

Q

0

G

0

H

1

I

0

L

1

K

2

M

1

F

0

P

0

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 1 C: 0 E: 3 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 1 M: 2 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

13

Formula

C70H114N18O24S2

Mass

1655.90

PI

4.16

Net Charge

-2

Boman Index

7.98

Hydrophobicity

-0.869

Chemical_Mass

1655.8880

Monoisotopic_Mass

1654.7668

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 69.84 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Song J. J., Wang Q., Du M., Ji X. M., Mao X. Y.

Title

Identification of Dipeptidyl Peptidase-IV Inhibitory Peptides from Mare Whey Protein Hydrolysates. J Dairy Sci, 100 (9), 6885–6894, 2017

Year 2017

Literature Source Journal

Other

Number of Residues 13

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C70H114N18O24S2/c1-8-36(4)56(68(110)83-44(27-31-113-6)61(103)78-41(20-24-50(91)92)59(101)77-39(17-12-13-29-71)57(99)85-47(33-38-15-10-9-11-16-38)64(106)84-46(69(111)112)18-14-30-76-70(74)75)88-62(104)43(22-26-52(95)96)79-60(102)42(21-25-51(93)94)80-65(107)48(34-53(97)98)86-67(109)55(35(2)3)87-63(105)45(28-32-114-7)81-58(100)40(19-23-49(72)90)82-66(108)54(73)37(5)89/h9-11,15-16,35-37,39-48,54-56,89H,8,12-14,17-34,71,73H2,1-7H3,(H2,72,90)(H,77,101)(H,78,103)(H,79,102)(H,80,107)(H,81,100)(H,82,108)(H,83,110)(H,84,106)(H,85,99)(H,86,109)(H,87,105)(H,88,104)(H,91,92)(H,93,94)(H,95,96)(H,97,98)(H,111,112)(H4,74,75,76)/t36-,37+,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,54-,55-,56-/m0/s1 InChIKey= QMNJKBJKRFNDDK-LTPFKKHESA-N

Number_of_Residues

13