TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB71796

Peptide_Name

Dipeptidyl peptidase IV inhibitor

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural idppiv peptide sequence curated from iDPPIV, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

PGVGGPLGPIGPCYE

FASTA

>TPDB71796|iDPPIV|length=15
PGVGGPLGPIGPCYE

Formula C64H97N15O19S1

Absent Amino Acids ARNDQHKMFSTW

Common Amino Acids G

Mass 1412.62

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -1

Boman Index 1.89

Hydrophobicity 0.120

Aliphatic Index 71.33

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 1490

Absorbance 280nm 105.48

Polar Residues 2

number

0

A

0

R

0

N

0

D

1

C

1

E

0

Q

5

G

0

H

1

I

1

L

0

K

0

M

0

F

4

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 5 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 4 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

15

Formula

C64H97N15O19S1

Mass

1412.62

PI

3.29

Net Charge

-1

Boman Index

1.89

Hydrophobicity

0.120

Chemical_Mass

1412.6063

Monoisotopic_Mass

1411.6783

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 116.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Huang SL, Jao CL, Ho KP, Hsu KC.

Title Dipeptidyl-peptidase IV inhibitory activity of peptides from tuna cooking juice hydrolysates. Peptides 2012 35: 114-21.

Year 2012

Literature Source Journal

Other

Number of Residues 15

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(O)=O)(NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@]([H])(CS)NC(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1C(=O)CNC(=O)CNC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@]1([H])CCCN1)C(C)C)[C@@H](C)CC)C(O)=O InChI=1S/C64H97N15O19S/c1-7-36(6)54(63(96)70-32-51(85)78-24-10-14-45(78)60(93)74-43(33-99)58(91)72-42(27-37-16-18-38(80)19-17-37)57(90)71-40(64(97)98)20-21-52(86)87)76-61(94)46-15-11-25-79(46)50(84)31-69-56(89)41(26-34(2)3)73-59(92)44-13-9-23-77(44)49(83)30-66-47(81)28-68-62(95)53(35(4)5)75-48(82)29-67-55(88)39-12-8-22-65-39/h16-19,34-36,39-46,53-54,65,80,99H,7-15,20-33H2,1-6H3,(H,66,81)(H,67,88)(H,68,95)(H,69,89)(H,70,96)(H,71,90)(H,72,91)(H,73,92)(H,74,93)(H,75,82)(H,76,94)(H,86,87)(H,97,98)/t36-,39-,40-,41-,42-,43-,44-,45-,46-,53-,54-/m0/s1 InChIKey: VPESKZOAPWSTAI-YHLASCSKSA-N

Number_of_Residues

15