TPDB

3D PDB MODEL

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TPDB ID TPDB71728

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.

Sequence

LTFPGSAED

FASTA

>TPDB71728|iDPPIV|length=9
LTFPGSAED

Formula C41H61N9O16

Absent Amino Acids RNCQHIKMWYV

Common Amino Acids ADEGLFPST

Mass 935.99

PI 3.01

Basic Residues 0

Acidic Residues 2

Hydrophobic Residues 3

Net Charge -2

Boman Index 2.12

Hydrophobicity -0.233

Aliphatic Index 54.44

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

0

R

0

N

1

D

0

C

1

E

0

Q

1

G

0

H

0

I

1

L

0

K

0

M

1

F

1

P

1

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0

Length

9

Formula

C41H61N9O16

Mass

935.99

PI

3.01

Net Charge

-2

Boman Index

2.12

Hydrophobicity

-0.233

Chemical_Mass

935.9713

Monoisotopic_Mass

935.4221

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 228.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lammi C., Zanoni C., Arnoldi A., Vistoli G.

Title

Peptides derived from soy and lupin protein as dipeptidyl-peptidase IV inhibitors: in vitro biochemical screening and in silico molecular modeling study. J. Agric. Food Chem., 2016, 64, 9601–9606

Year 2016

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](C(O)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1[C@@H](CCC1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O InChI=1S/C41H61N9O16/c1-20(2)15-24(42)35(59)49-33(22(4)52)39(63)47-26(16-23-9-6-5-7-10-23)40(64)50-14-8-11-29(50)38(62)43-18-30(53)45-28(19-51)37(61)44-21(3)34(58)46-25(12-13-31(54)55)36(60)48-27(41(65)66)17-32(56)57/h5-7,9-10,20-22,24-29,33,51-52H,8,11-19,42H2,1-4H3,(H,43,62)(H,44,61)(H,45,53)(H,46,58)(H,47,63)(H,48,60)(H,49,59)(H,54,55)(H,56,57)(H,65,66)/t21-,22?,24-,25-,26-,27-,28-,29-,33-/m0/s1 InChIKey: IBTVFVCXPZUCFW-KZXSYCCGSA-N

Number_of_Residues

9