TPDB

3D PDB MODEL

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TPDB ID TPDB71710

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural idppiv peptide sequence curated from iDPPIV, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

LPIIDI

FASTA

>TPDB71710|iDPPIV|length=6
LPIIDI

Formula C33H58N6O9

Absent Amino Acids ARNCEQGHKMFSTWYV

Common Amino Acids I

Mass 682.86

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -1

Boman Index 0.19

Hydrophobicity 2.033

Aliphatic Index 260.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

3

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

6

Formula

C33H58N6O9

Mass

682.86

PI

3.10

Net Charge

-1

Boman Index

0.19

Hydrophobicity

2.033

Chemical_Mass

682.8461

Monoisotopic_Mass

682.4251

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 105.44 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Zhang Y., Chen R., Chen X., Zeng Z., Ma H., Chen S.

Title

Dipeptidyl peptidase IV-inhibitory peptides derived from silver carp (Hypophthalmichthys molitrix Val.) proteins. J. Agric. Food Chem., 64, 831-839, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(O)=O)C(O)=O InChI=1S/C33H58N6O9/c1-9-18(6)25(30(44)35-22(16-24(40)41)28(42)38-27(33(47)48)20(8)11-3)37-31(45)26(19(7)10-2)36-29(43)23-13-12-14-39(23)32(46)21(34)15-17(4)5/h17-23,25-27H,9-16,34H2,1-8H3,(H,35,44)(H,36,43)(H,37,45)(H,38,42)(H,40,41)(H,47,48)/t18-,19-,20-,21-,22-,23-,25-,26-,27-/m0/s1 InChIKey= PNMORPFFFCHACT-ATQATTBRSA-N

Number_of_Residues

6