TPDB

3D PDB MODEL

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TPDB ID TPDB71700

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural idppiv peptide sequence curated from iDPPIV, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

LKPTPEGDLEIL

FASTA

>TPDB71700|iDPPIV|length=12
LKPTPEGDLEIL

Formula C60H101N13O20

Absent Amino Acids ARNCQHMFSWYV

Common Amino Acids L

Mass 1324.54

PI 3.83

Basic Residues 1

Acidic Residues 3

Hydrophobic Residues 4

Net Charge -2

Boman Index 5.32

Hydrophobicity -0.233

Aliphatic Index 130.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

1

D

0

C

2

E

0

Q

1

G

0

H

1

I

3

L

1

K

0

M

0

F

2

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 1 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

12

Formula

C60H101N13O20

Mass

1324.54

PI

3.83

Net Charge

-2

Boman Index

5.32

Hydrophobicity

-0.233

Chemical_Mass

1324.5150

Monoisotopic_Mass

1323.7261

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 57.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lacroix I. M. E., Li-Chan E. C. Y.

Title

Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins. Peptides, 54, 39-48.

Year 2014

Literature Source Journal

Other

Number of Residues 12

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C60H101N13O20/c1-10-33(8)48(57(89)69-41(60(92)93)27-32(6)7)70-52(84)37(19-21-46(78)79)65-53(85)39(26-31(4)5)68-54(86)40(28-47(80)81)64-44(75)29-63-51(83)36(18-20-45(76)77)66-55(87)42-16-14-24-73(42)59(91)49(34(9)74)71-56(88)43-17-13-23-72(43)58(90)38(15-11-12-22-61)67-50(82)35(62)25-30(2)3/h30-43,48-49,74H,10-29,61-62H2,1-9H3,(H,63,83)(H,64,75)(H,65,85)(H,66,87)(H,67,82)(H,68,86)(H,69,89)(H,70,84)(H,71,88)(H,76,77)(H,78,79)(H,80,81)(H,92,93)/t33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,48-,49-/m0/s1 InChIKey= QSUPAGYATLENCN-YKGXBYSXSA-N

Number_of_Residues

12