TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB71699

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.

Sequence

LKPTPEGDLE

FASTA

>TPDB71699|iDPPIV|length=10
LKPTPEGDLE

Formula C48H79N11O18

Absent Amino Acids ARNCQHIMFSWYV

Common Amino Acids ELP

Mass 1098.22

PI 3.83

Basic Residues 1

Acidic Residues 3

Hydrophobic Residues 2

Net Charge -2

Boman Index 6.19

Hydrophobicity -1.110

Aliphatic Index 78.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

1

D

0

C

2

E

0

Q

1

G

0

H

0

I

2

L

1

K

0

M

0

F

2

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 1 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

10

Formula

C48H79N11O18

Mass

1098.22

PI

3.83

Net Charge

-2

Boman Index

6.19

Hydrophobicity

-1.110

Chemical_Mass

1098.2006

Monoisotopic_Mass

1097.5585

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 42.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lacroix I. M. E., Meng G., Cheung I. W. Y., Li-Chan E. C. Y.

Title

Do whey protein-derived peptides have dual dipeptidyl-peptidase IV and angiotensin I-converting enzyme inhibitory activities? J Funct Foods, 21, 87–96, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C48H79N11O18/c1-24(2)20-27(50)40(68)54-29(10-6-7-17-49)46(74)58-18-8-12-34(58)45(73)57-39(26(5)60)47(75)59-19-9-11-33(59)44(72)53-28(13-15-36(62)63)41(69)51-23-35(61)52-32(22-38(66)67)43(71)56-31(21-25(3)4)42(70)55-30(48(76)77)14-16-37(64)65/h24-34,39,60H,6-23,49-50H2,1-5H3,(H,51,69)(H,52,61)(H,53,72)(H,54,68)(H,55,70)(H,56,71)(H,57,73)(H,62,63)(H,64,65)(H,66,67)(H,76,77)/t26-,27+,28+,29+,30+,31+,32+,33+,34+,39+/m1/s1 InChIKey= GGFCKAGNOZUZFE-OTRJRROOSA-N

Number_of_Residues

10