TPDB

3D PDB MODEL

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TPDB ID TPDB71698

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.

Sequence

LKPTPEGDL

FASTA

>TPDB71698|iDPPIV|length=9
LKPTPEGDL

Formula C43H72N10O15

Absent Amino Acids ARNCQHIMFSWYV

Common Amino Acids LP

Mass 969.10

PI 4.07

Basic Residues 1

Acidic Residues 2

Hydrophobic Residues 2

Net Charge -1

Boman Index 4.17

Hydrophobicity -0.844

Aliphatic Index 86.67

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

1

D

0

C

1

E

0

Q

1

G

0

H

0

I

2

L

1

K

0

M

0

F

2

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 1 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

9

Formula

C43H72N10O15

Mass

969.10

PI

4.07

Net Charge

-1

Boman Index

4.17

Hydrophobicity

-0.844

Chemical_Mass

969.0869

Monoisotopic_Mass

968.5161

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 45.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lacroix I. M. E., Li-Chan E. C. Y.

Title

Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins. Peptides, 54, 39-48.

Year 2014

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C43H72N10O15/c1-22(2)18-25(45)36(60)49-27(10-6-7-15-44)41(65)52-16-8-12-31(52)40(64)51-35(24(5)54)42(66)53-17-9-11-30(53)39(63)48-26(13-14-33(56)57)37(61)46-21-32(55)47-28(20-34(58)59)38(62)50-29(43(67)68)19-23(3)4/h22-31,35,54H,6-21,44-45H2,1-5H3,(H,46,61)(H,47,55)(H,48,63)(H,49,60)(H,50,62)(H,51,64)(H,56,57)(H,58,59)(H,67,68)/t24-,25+,26+,27+,28+,29+,30-,31-,35+/m1/s1 InChIKey: QAAFYGADSHNWTA-OOZJMILQSA-N

Number_of_Residues

9