TPDB

3D PDB MODEL

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TPDB ID TPDB71671

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.

Sequence

IPGDPGPPGPPGP

FASTA

>TPDB71671|iDPPIV|length=13
IPGDPGPPGPPGP

Formula C53H79N13O16

Absent Amino Acids ARNCEQHLKMFSTWYV

Common Amino Acids P

Mass 1154.29

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -1

Boman Index 4.11

Hydrophobicity -0.908

Aliphatic Index 30.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

4

G

0

H

1

I

0

L

0

K

0

M

0

F

7

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 7 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

13

Formula

C53H79N13O16

Mass

1154.29

PI

3.10

Net Charge

-1

Boman Index

4.11

Hydrophobicity

-0.908

Chemical_Mass

1154.2687

Monoisotopic_Mass

1153.5749

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 65.40 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Wang T. Y., Hsieh C. H., Hung C. C., Jao C. L., Chen M. C., Hsu K. C.

Title

Fish skin gelatin hydrolysates as dipeptidyl peptidase IV inhibitors and glucagon-like peptide-1 stimulators improve glycaemic control in diabetic rats: A Comparison between Warm- and Cold-Water Fish. J Funct Foods, 19, 330–340, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 13

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C53H79N13O16/c1-3-30(2)44(54)52(80)66-24-7-14-35(66)45(73)55-26-39(67)59-31(25-43(71)72)49(77)63-21-4-11-32(63)46(74)56-27-40(68)60-18-8-15-36(60)50(78)64-22-5-12-33(64)47(75)57-28-41(69)61-19-9-16-37(61)51(79)65-23-6-13-34(65)48(76)58-29-42(70)62-20-10-17-38(62)53(81)82/h30-38,44H,3-29,54H2,1-2H3,(H,55,73)(H,56,74)(H,57,75)(H,58,76)(H,59,67)(H,71,72)(H,81,82)/t30-,31-,32-,33-,34-,35-,36-,37-,38-,44-/m0/s1 InChIKey= NWHZQBGTABYAIK-RXUMBGRESA-N

Number_of_Residues

13