TPDB

3D PDB MODEL

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TPDB ID TPDB71668

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural idppiv peptide sequence curated from iDPPIV, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

INNQFLPYPY

FASTA

>TPDB71668|iDPPIV|length=10
INNQFLPYPY

Formula C62H85N13O16

Absent Amino Acids ARDCEGHKMSTWV

Common Amino Acids NPY

Mass 1268.43

PI 5.88

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 5

Net Charge -0

Boman Index -1.56

Hydrophobicity -0.520

Aliphatic Index 78.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 234.94

Polar Residues 5

number

0

A

0

R

2

N

0

D

0

C

0

E

1

Q

0

G

0

H

1

I

1

L

0

K

0

M

1

F

2

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

10

Formula

C62H85N13O16

Mass

1268.43

PI

5.88

Net Charge

-0

Boman Index

-1.56

Hydrophobicity

-0.520

Chemical_Mass

1268.4124

Monoisotopic_Mass

1267.6217

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity iDPPIV

Activity Measurement 40.08 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Zhang Y., Chen R., Ma H., Chen S.

Title

Isolation and identification of dipeptidyl peptidase IV-inhibitory peptides from trypsin/chymotrypsin-treated goat milk casein hydrolysates by 2D-TLC and LC–MS/MS. Journal of Agricultural and Food Chemistry, 2015, 63, 8819-8828.

Year 2015

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C62H85N13O16/c1-5-34(4)52(66)59(87)70-43(32-51(65)80)56(84)69-42(31-50(64)79)55(83)67-40(23-24-49(63)78)53(81)68-41(28-35-11-7-6-8-12-35)54(82)71-44(27-33(2)3)60(88)74-25-9-13-47(74)57(85)72-45(29-36-15-19-38(76)20-16-36)61(89)75-26-10-14-48(75)58(86)73-46(62(90)91)30-37-17-21-39(77)22-18-37/h6-8,11-12,15-22,33-34,40-48,52,76-77H,5,9-10,13-14,23-32,66H2,1-4H3,(H2,63,78)(H2,64,79)(H2,65,80)(H,67,83)(H,68,81)(H,69,84)(H,70,87)(H,71,82)(H,72,85)(H,73,86)(H,90,91)/t34-,40-,41-,42-,43-,44-,45-,46-,47-,48-,52-/m0/s1 InChIKey: LHNKWRIPYIRUTK-IWQDERRMSA-N

Number_of_Residues

10