TPDB

3D PDB MODEL

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TPDB ID TPDB71650

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural idppiv peptide sequence curated from iDPPIV, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

HPINHR

FASTA

>TPDB71650|iDPPIV|length=6
HPINHR

Formula C33H52N14O8

Absent Amino Acids ADCEQGLKMFSTWYV

Common Amino Acids H

Mass 772.86

PI 11.05

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +1

Boman Index 3.29

Hydrophobicity -1.917

Aliphatic Index 65.00

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

1

R

1

N

0

D

0

C

0

E

0

Q

0

G

2

H

1

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

6

Formula

C33H52N14O8

Mass

772.86

PI

11.05

Net Charge

+1

Boman Index

3.29

Hydrophobicity

-1.917

Chemical_Mass

772.8529

Monoisotopic_Mass

772.4082

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 452.20 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Zhang Y., Chen R., Zuo F., Ma H., Zhang Y., Chen S.

Title

Comparison of dipeptidyl peptidase IV-inhibitory activity of peptides from bovine and caprine milk casein by in silico and in vitro analyses. Int. Dairy J., 53, 37-44, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C33H52N14O8/c1-3-17(2)26(46-29(51)24-7-5-9-47(24)31(53)20(34)10-18-13-38-15-41-18)30(52)45-23(12-25(35)48)28(50)44-22(11-19-14-39-16-42-19)27(49)43-21(32(54)55)6-4-8-40-33(36)37/h13-17,20-24,26H,3-12,34H2,1-2H3,(H2,35,48)(H,38,41)(H,39,42)(H,43,49)(H,44,50)(H,45,52)(H,46,51)(H,54,55)(H4,36,37,40)/t17-,20-,21-,22-,23-,24-,26-/m0/s1 InChIKey=WWSZIEJXAMNSAP-OINKWOPSSA-N

Number_of_Residues

6