TPDB

3D PDB MODEL

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TPDB ID TPDB71640

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

iDPPIV pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural idppiv peptide sequence curated from iDPPIV, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

GPPPPGPPPI

FASTA

>TPDB71640|iDPPIV|length=10
GPPPPGPPPI

Formula C45H68N10O11

Absent Amino Acids ARNDCEQHLKMFSTWYV

Common Amino Acids P

Mass 925.10

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index 2.86

Hydrophobicity -0.750

Aliphatic Index 39.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

1

I

0

L

0

K

0

M

0

F

7

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 7 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

10

Formula

C45H68N10O11

Mass

925.10

PI

6.02

Net Charge

-0

Boman Index

2.86

Hydrophobicity

-0.750

Chemical_Mass

925.0791

Monoisotopic_Mass

924.5053

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 500.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lacroix I. M. E., Li-Chan E. C. Y.

Title

Evaluation of the potential of dietary proteins as precursors of dipeptidyl peptidase (DPP)-IV inhibitors by an in silico approach. J. Funct. Foods, 4, 403-422

Year 2012

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)CN)C(O)=O InChI=1S/C45H68N10O11/c1-3-27(2)37(45(65)66)48-39(59)29-12-5-21-52(29)43(63)33-16-8-22-53(33)41(61)31-14-7-19-50(31)36(57)26-47-38(58)28-11-4-20-51(28)42(62)32-15-9-24-55(32)44(64)34-17-10-23-54(34)40(60)30-13-6-18-49(30)35(56)25-46/h27-34,37H,3-26,46H2,1-2H3,(H,47,58)(H,48,59)(H,65,66)/t27-,28-,29-,30-,31-,32-,33-,34-,37-/m0/s1 InChIKey=WTMGGHFYHAKEIM-UBZVIJGOSA-N Information concerning Dipeptidyl Peptidase IV (synonym: Dipeptidyl Aminopeptidase IV) (EC 3.4.14.5) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003 Peptide found in amaranth (Amarantus hypochondriacus) proteins: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) according to AHTPDB database BIOPEP database of bioactive peptides (ID 3502) EROP-Moscow database Antifungal peptide according to EROP-Moscow database Bitter peptide according to BIOPEP database of sensory peptides and amino acids EROP-Moscow database

Number_of_Residues

10