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Peptide record

TPDB71636

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) iDPPIV standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB71636
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
iDPPIV
Cardiometabolic peptides
iDPPIV Peptipedia
standard
No
A 4-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.
Sequence
GPGA
Physicochemical Analysis
C12H20N4O5
RNDCEQHILKMFSTWYV
G
300.31
6.02
0
0
1
-0
0.30
-0.150
25.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C12H20N4O5
300.31
6.02
-0
0.30
-0.150
300.3102
300.1429
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
iDPPIV
41.90 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Zheng L., Xu Q., Lin L., Zeng X. A., Sun B., Zhao M.
In vitro metabolic stability of a casein-derived dipeptidyl peptidase-IV (DPP-IV) inhibitory peptide VPYPQ and its controlled release from casein by enzymatic hydrolysis. J Agric Food Chem, 67 (38), 10604–10613, 2019
2019
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C12H20N4O5/c1-7(12(20)21)15-9(17)6-14-11(19)8-3-2-4-16(8)10(18)5-13/h7-8H,2-6,13H2,1H3,(H,14,19)(H,15,17)(H,20,21)/t7-,8-/m0/s1 InChIKey= SMQXQCKNIFGBNY-YUMQZZPRSA-N
Additional Detail Fields 1 fields
4