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Peptide record

TPDB71582

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) iDPPIV standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB71582
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
iDPPIV
Cardiometabolic peptides
iDPPIV Peptipedia
standard
No
A 5-aa standard natural idppiv peptide sequence curated from iDPPIV and Peptipedia, with an available 3D structural model.
Sequence
APFPE
Physicochemical Analysis
C27H37N5O8
RNDCQGHILKMSTWYV
P
559.62
3.29
0
1
2
-1
1.62
-0.420
20.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C27H37N5O8
559.62
3.29
-1
1.62
-0.420
559.6099
559.2633
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
iDPPIV
49.50 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Martini S., Solieri L., Cattivelli A., Pizzamiglio V., Tagliazucchi D.
An integrated peptidomics and in silico approach to identify novel anti-diabetic peptides in parmigiano-reggiano cheese. Biology 2021, Vol. 10, Page 563, 10 (6), 563, 2021
2021
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C27H37N5O8/c1-16(28)25(37)31-13-5-9-20(31)24(36)30-19(15-17-7-3-2-4-8-17)26(38)32-14-6-10-21(32)23(35)29-18(27(39)40)11-12-22(33)34/h2-4,7-8,16,18-21H,5-6,9-15,28H2,1H3,(H,29,35)(H,30,36)(H,33,34)(H,39,40)/t16-,18-,19-,20-,21-/m0/s1 InChIKey= JVIBCQYJZKRBPW-MQBSTWLZSA-N
Additional Detail Fields 1 fields
5