TPDB

3D PDB MODEL

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TPDB ID TPDB71575

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Umami iDPPIV

Activity_category_statistics

Cardiometabolic peptides Food sensory peptides

Database_Source

Tastepeptides-Meta iDPPIV Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Umami and iDPPIV) peptide sequence curated from Tastepeptides-Meta, iDPPIV, and Peptipedia, with an available 3D structural model.

Sequence

AE

FASTA

>TPDB71575|Umami;iDPPIV|length=2
AE

Formula C8H14N2O5

Absent Amino Acids RNDCQGHILKMFPSTWYV

Common Amino Acids AE

Mass 218.21

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -1

Boman Index 1.85

Hydrophobicity -0.850

Aliphatic Index 50.00

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

2

Formula

C8H14N2O5

Mass

218.21

PI

3.29

Net Charge

-1

Boman Index

1.85

Hydrophobicity

-0.850

Chemical_Mass

218.2066

Monoisotopic_Mass

218.0899

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 0.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.

Title Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)O)C InChI=1S/C8H14N2O5/c1-4(9)7(13)10-5(8(14)15)2-3-6(11)12/h4-5H,2-3,9H2,1H3,(H,10,13)(H,11,12)(H,14,15)/t4-,5-/m0/s1 InChIKey: VYZAGTDAHUIRQA-WHFBIAKZSA-N Inhibitor of Glutamate carboxypeptidase (EC 3.4.17.11) (MEROPS ID: M20.001) according to the BRENDA database Inhibitor of Glutamate carboxypeptidase II (EC 3.4.17.21) (MEROPS ID: M28.010) according to the BRENDA database Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 349) the EROP-Moscow database

Number_of_Residues

2