TPDB

3D PDB MODEL

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TPDB ID TPDB71268

Peptide_Name

Anti-inflammatory peptide

Activity

Anti-inflammatory

Activity_category_statistics

Immunity and inflammation peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural anti-inflammatory peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

NSPGPHDVALDQ

FASTA

>TPDB71268|Anti-inflammatory|length=12
NSPGPHDVALDQ

Formula C52H80N16O20

Absent Amino Acids RCEIKMFTWY

Common Amino Acids DP

Mass 1249.30

PI 3.88

Basic Residues 1

Acidic Residues 2

Hydrophobic Residues 3

Net Charge -2

Boman Index 4.80

Hydrophobicity -0.983

Aliphatic Index 65.00

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

1

A

0

R

1

N

2

D

0

C

0

E

1

Q

1

G

1

H

0

I

1

L

0

K

0

M

0

F

2

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 2 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

12

Formula

C52H80N16O20

Mass

1249.30

PI

3.88

Net Charge

-2

Boman Index

4.80

Hydrophobicity

-0.983

Chemical_Mass

1249.2836

Monoisotopic_Mass

1248.5716

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Function Anti-inflammatory peptide

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Grancieri M., Duarte Martino H. S., Gonzalez de Mejia E.

Title

Protein digests and pure peptides from chia seed prevented adipogenesis and inflammation by inhibiting PPARgamma and NF-kappaB pathways in 3T3L-1 adipocytes. Nutrients, 13, 176, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 12

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C52H80N16O20/c1-23(2)14-29(44(79)62-31(17-39(73)74)46(81)60-28(52(87)88)10-11-36(54)70)61-42(77)25(5)59-50(85)41(24(3)4)66-47(82)32(18-40(75)76)63-45(80)30(15-26-19-56-22-58-26)64-49(84)35-9-6-12-67(35)38(72)20-57-48(83)34-8-7-13-68(34)51(86)33(21-69)65-43(78)27(53)16-37(55)71/h19,22-25,27-35,41,69H,6-18,20-21,53H2,1-5H3,(H2,54,70)(H2,55,71)(H,56,58)(H,57,83)(H,59,85)(H,60,81)(H,61,77)(H,62,79)(H,63,80)(H,64,84)(H,65,78)(H,66,82)(H,73,74)(H,75,76)(H,87,88)/t25-,27-,28-,29-,30-,31-,32-,33-,34-,35-,41-/m0/s1 InChIKey=AXXQVJHTFXAECG-YQXCQCMMSA-N Inhibitor of adipogenesis according to the BIOPEP-UWM database of bioactive peptides (ID 9924)

Number_of_Residues

12