TPDB

3D PDB MODEL

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TPDB ID TPDB71140

Peptide_Name

Anti-inflammatory peptide

Activity

Anti-inflammatory

Activity_category_statistics

Immunity and inflammation peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural anti-inflammatory peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

FDLIYSV

FASTA

>TPDB71140|Anti-inflammatory|length=7
FDLIYSV

Formula C42H61N7O12

Absent Amino Acids ARNCEQGHKMPTW

Common Amino Acids DILFSYV

Mass 855.99

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 5

Net Charge -1

Boman Index -1.51

Hydrophobicity 1.386

Aliphatic Index 152.86

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 174.07

Polar Residues 2

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

1

I

1

L

0

K

0

M

1

F

0

P

1

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 1

Length

7

Formula

C42H61N7O12

Mass

855.99

PI

3.10

Net Charge

-1

Boman Index

-1.51

Hydrophobicity

1.386

Chemical_Mass

855.9710

Monoisotopic_Mass

855.4363

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Function Anti-inflammatory

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Wang S., Zheng L., Zhao T., Zhang Q., Liu Y., Sun B., Su G., Zhao M.

Title

Inhibitory effects of walnut (Juglans regia) peptides on neuroinflammation and oxidative stress in lipopolysaccharide-induced cognitive impairment mice. J. Agric. Food Chem., 68, 2381-2392, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)O InChI=1S/C42H61N7O12/c1-7-24(6)35(41(59)46-30(19-26-13-15-27(51)16-14-26)37(55)47-32(21-50)40(58)48-34(23(4)5)42(60)61)49-39(57)29(17-22(2)3)45-38(56)31(20-33(52)53)44-36(54)28(43)18-25-11-9-8-10-12-25/h8-16,22-24,28-32,34-35,50-51H,7,17-21,43H2,1-6H3,(H,44,54)(H,45,56)(H,46,59)(H,47,55)(H,48,58)(H,49,57)(H,52,53)(H,60,61)/t24-,28-,29-,30-,31-,32-,34-,35-/m0/s1 InChIKey=YHRWQXNJGMYJGX-GLVXAEIMSA-N

Number_of_Residues

7