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Peptide record

TPDB67564

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antidiabetic standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB67564
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
YPGE
Physicochemical Analysis
C21H28N4O8
ARNDCQHILKMFSTWV
EGPY
464.48
3.29
0
1
1
-1
1.54
-1.700
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
320.79
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
4
C21H28N4O8
464.48
3.29
-1
1.54
-1.700
464.4679
464.1900
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
40.90 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Xiang, X. Lang, M. Li, Y. Zhao, X. Sun, H. Jiang, W. Ni, L. Song, Y.
Purification, identification and molecular mechanism of dipeptidyl peptidase IV inhibitory peptides from discarded shrimp (penaeus vannamei) head. Journal of Chromatography B, 1186, 122990, 2021
2021
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C21H28N4O8/c22-14(10-12-3-5-13(26)6-4-12)20(31)25-9-1-2-16(25)19(30)23-11-17(27)24-15(21(32)33)7-8-18(28)29/h3-6,14-16,26H,1-2,7-11,22H2,(H,23,30)(H,24,27)(H,28,29)(H,32,33)/t14-,15-,16-/m0/s1 InChIKey= PLZFBVRMQLGNSX-JYJNAYRXSA-N
Additional Detail Fields 1 fields
4