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Peptide record

TPDB67511

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antidiabetic standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB67511
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
VPTP
Physicochemical Analysis
C19H32N4O6
ARNDCEQGHILKMFSWY
P
412.49
6.02
0
0
1
-0
1.11
0.075
72.50
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
4
C19H32N4O6
412.49
6.02
-0
1.11
0.075
412.4793
412.2314
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
38.93 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Harnedy-Rothwell P. A., McLaughlin C. M., O’Keeffe M. B., le Gouic A. v., Allsopp P. J., McSorley E. M., Sharkey S., Whooley J., McGovern B., et al.
Identification and characterisation of peptides from a boarfish (capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity. Food Research International, 131, 108989, 2020
2020
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C19H32N4O6/c1-10(2)14(20)17(26)22-8-4-6-12(22)16(25)21-15(11(3)24)18(27)23-9-5-7-13(23)19(28)29/h10-15,24H,4-9,20H2,1-3H3,(H,21,25)(H,28,29)/t11-,12+,13+,14+,15+/m1/s1 InChIKey= XCLAOQRZKJDBFQ-QTVXIADOSA-N
Additional Detail Fields 1 fields
4