TPDB

3D PDB MODEL

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TPDB ID TPDB67508

Peptide_Name

Antidiabetic peptide Dipeptidyl peptidase IV (DPPIV) inhibitor

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

VPLVM

FASTA

>TPDB67508|Antidiabetic|length=5
VPLVM

Formula C26H47N5O6S1

Absent Amino Acids ARNDCEQGHIKFSTWY

Common Amino Acids V

Mass 557.75

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 4

Net Charge -0

Boman Index -0.20

Hydrophobicity 2.500

Aliphatic Index 194.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

1

M

0

F

1

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

5

Formula

C26H47N5O6S1

Mass

557.75

PI

6.02

Net Charge

-0

Boman Index

-0.20

Hydrophobicity

2.500

Chemical_Mass

557.7455

Monoisotopic_Mass

557.3236

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 99.68 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Pei J., Liu Z., Pan D., Zhao Y., Dang Y., Gao X.

Title

Transport, stability, and in vivo hypoglycemic effect of a broccoli-derived DPP-IV inhibitory peptide VPLVM. J. Agric. Food Chem., 70, 4934–4941, 2022

Year 2022

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)O InChI=1S/C26H47N5O6S/c1-14(2)13-18(29-23(33)19-9-8-11-31(19)25(35)20(27)15(3)4)22(32)30-21(16(5)6)24(34)28-17(26(36)37)10-12-38-7/h14-21H,8-13,27H2,1-7H3,(H,28,34)(H,29,33)(H,30,32)(H,36,37)/t17-,18-,19-,20-,21-/m0/s1 InChIKey=WTUQPUDBBBAMBB-UDZSMLTASA-N Antidiabetic peptide according to the BIOPEP-UWM database of bioactive peptides

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 99.68 µM

Function Hypoglycemic effect in vivo

Detail Activity antidiabetic

Activity Code adb

Source & Reference

Database Source NA

Authors Pei J., Liu Z., Pan D., Zhao Y., Dang Y., Gao X.

Title

Transport, stability, and in vivo hypoglycemic effect of a broccoli-derived DPP-IV inhibitory peptide VPLVM. J. Agric. Food Chem., 70, 4934–4941, 2022

Year 2022

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)O InChI=1S/C26H47N5O6S/c1-14(2)13-18(29-23(33)19-9-8-11-31(19)25(35)20(27)15(3)4)22(32)30-21(16(5)6)24(34)28-17(26(36)37)10-12-38-7/h14-21H,8-13,27H2,1-7H3,(H,28,34)(H,29,33)(H,30,32)(H,36,37)/t17-,18-,19-,20-,21-/m0/s1 InChIKey=WTUQPUDBBBAMBB-UDZSMLTASA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides

Number_of_Residues

5