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Peptide record

TPDB67506

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antidiabetic standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB67506
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
VPIP
Physicochemical Analysis
C21H36N4O5
ARNDCEQGHLKMFSTWY
P
424.54
6.02
0
0
2
-0
0.66
1.375
170.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
4
C21H36N4O5
424.54
6.02
-0
0.66
1.375
424.5329
424.2677
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
54.69 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Cermeño M., Connolly A., O’Keeffe M. B., Flynn C., Alashi A. M., Aluko R. E., FitzGerald R. J.
Identification of bioactive peptides from brewers’ spent grain and contribution of Leu/Ile to Bioactive Potency. J Funct Foods, 60, 103455, 2019
2019
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C21H36N4O5/c1-5-13(4)17(20(28)25-11-7-9-15(25)21(29)30)23-18(26)14-8-6-10-24(14)19(27)16(22)12(2)3/h12-17H,5-11,22H2,1-4H3,(H,23,26)(H,29,30)/t13-,14-,15-,16-,17-/m0/s1 InChIKey= USMPDEJRUUXVQB-WOYTXXSLSA-N
Additional Detail Fields 1 fields
4