TPDB

3D PDB MODEL

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TPDB ID TPDB67468

Peptide_Name

DPPIV inhibitor

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural antidiabetic peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

VADTMEVV

FASTA

>TPDB67468|Antidiabetic|length=8
VADTMEVV

Formula C36H62N8O14S1

Absent Amino Acids RNCQGHILKFPSWY

Common Amino Acids V

Mass 862.99

PI 3.01

Basic Residues 0

Acidic Residues 2

Hydrophobic Residues 5

Net Charge -2

Boman Index 3.20

Hydrophobicity 1.075

Aliphatic Index 121.25

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

0

N

1

D

0

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

1

M

0

F

0

P

0

S

1

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 3

Length

8

Formula

C36H62N8O14S1

Mass

862.99

PI

3.01

Net Charge

-2

Boman Index

3.20

Hydrophobicity

1.075

Chemical_Mass

862.9863

Monoisotopic_Mass

862.4091

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 603.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Theysgeur S., Cudennec B., Deracinois B., Perrin C., Guiller I., Lepoudère A., Flahaut C., Ravallec R.

Title

New bioactive peptides identified from a tilapia byproduct hydrolysate exerting effects on DPP-IV activity and intestinal hormones regulation after canine gastrointestinal simulated digestion. Molecules, 26, 136, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C36H62N8O14S/c1-15(2)25(37)33(54)38-18(7)29(50)41-22(14-24(48)49)32(53)44-28(19(8)45)35(56)40-21(12-13-59-9)30(51)39-20(10-11-23(46)47)31(52)42-26(16(3)4)34(55)43-27(17(5)6)36(57)58/h15-22,25-28,45H,10-14,37H2,1-9H3,(H,38,54)(H,39,51)(H,40,56)(H,41,50)(H,42,52)(H,43,55)(H,44,53)(H,46,47)(H,48,49)(H,57,58)/t18-,19+,20-,21-,22-,25-,26-,27-,28-/m0/s1 InChIKey=VYWBFQUVIXLIKM-UNTGQMNCSA-N

Number_of_Residues

8