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Peptide record

TPDB67466

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antidiabetic standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB67466
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
VAAA
Physicochemical Analysis
C14H26N4O5
RNDCEQGHILKMFPSTWY
A
330.38
6.02
0
0
4
-0
-0.44
2.400
147.50
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
4
C14H26N4O5
330.38
6.02
-0
-0.44
2.400
330.3790
330.1897
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
141.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Caron J., Cudennec B., Domenger D., Belguesmia Y., Flahaut C., Kouach, M., Lesage J., Goossens J-F, Dhulster P., Ravallec R.
Simulated GI digestion of dietary protein: release of new bioactive peptides involved in gut hormone secretion. Food Research International, 89, 2016, 382-390.
2016
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C14H26N4O5/c1-6(2)10(15)13(21)17-8(4)11(19)16-7(3)12(20)18-9(5)14(22)23/h6-10H,15H2,1-5H3,(H,16,19)(H,17,21)(H,18,20)(H,22,23)/t7-,8-,9-,10-/m0/s1 InChIKey: QDECZYDBLKJAPF-XKNYDFJKSA-N
Additional Detail Fields 1 fields
4