TPDB

3D PDB MODEL

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TPDB ID TPDB67396

Peptide_Name

Antidiabetic peptide from goat milk β-casein f30–40

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

SLSSSEESITH

FASTA

>TPDB67396|Antidiabetic|length=11
SLSSSEESITH

Formula C47H77N13O22

Absent Amino Acids ARNDCQGKMFPWYV

Common Amino Acids S

Mass 1176.20

PI 4.25

Basic Residues 1

Acidic Residues 2

Hydrophobic Residues 2

Net Charge -2

Boman Index 4.92

Hydrophobicity -0.600

Aliphatic Index 70.91

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 6

number

0

A

0

R

0

N

0

D

0

C

2

E

0

Q

0

G

1

H

1

I

1

L

0

K

0

M

0

F

0

P

5

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 1 I: 1 L: 1 K: 0 M: 0 F: 0 P: 0 S: 5 T: 1 W: 0 Y: 0 V: 0

Length

11

Formula

C47H77N13O22

Mass

1176.20

PI

4.25

Net Charge

-2

Boman Index

4.92

Hydrophobicity

-0.600

Chemical_Mass

1176.1851

Monoisotopic_Mass

1175.5287

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antidiabetic

Activity Measurement 0.00 µM

Function Ameliorating high-glucose-induced insulin resistance in HepG2 cells

Detail Activity antidiabetic

Activity Code adb

Source & Reference

Database Source NA

Authors Gong H., Gao J., Wang Y., Luo Q.W., Guo K.R., Ren F.Z., Mao X.Y.

Title

Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells. J. Dairy Sci., 103, 4907-4918, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 11

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O InChI=1S/C47H77N13O22/c1-6-21(4)35(45(79)60-36(22(5)66)46(80)54-28(47(81)82)12-23-13-49-19-50-23)59-44(78)32(18-65)55-39(73)26(8-10-34(69)70)51-38(72)25(7-9-33(67)68)52-41(75)29(15-62)57-43(77)31(17-64)58-42(76)30(16-63)56-40(74)27(11-20(2)3)53-37(71)24(48)14-61/h13,19-22,24-32,35-36,61-66H,6-12,14-18,48H2,1-5H3,(H,49,50)(H,51,72)(H,52,75)(H,53,71)(H,54,80)(H,55,73)(H,56,74)(H,57,77)(H,58,76)(H,59,78)(H,60,79)(H,67,68)(H,69,70)(H,81,82)/t21-,22+,24-,25-,26-,27-,28-,29-,30-,31-,32-,35-,36-/m0/s1 InChIKey=JSRRHOCCGBYTBO-CKOPEUTBSA-N

Number_of_Residues

11