TPDB

3D PDB MODEL

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TPDB ID TPDB67376

Peptide_Name

Dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

SGVSLAALKKALAAAGYDVEK

FASTA

>TPDB67376|Antidiabetic|length=21
SGVSLAALKKALAAAGYDVEK

Formula C92H156N24O29

Absent Amino Acids RNCQHIMFPTW

Common Amino Acids A

Mass 2062.39

PI 9.58

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 12

Net Charge +1

Boman Index 3.00

Hydrophobicity 0.390

Aliphatic Index 111.90

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 72.25

Polar Residues 3

number

6

A

0

R

0

N

1

D

0

C

1

E

0

Q

2

G

0

H

0

I

3

L

3

K

0

M

0

F

0

P

2

S

0

T

0

W

1

Y

2

V

Amino Acid Distribution

A: 6 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 3 K: 3 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 2

Length

21

Formula

C92H156N24O29

Mass

2062.39

PI

9.58

Net Charge

+1

Boman Index

3.00

Hydrophobicity

0.390

Chemical_Mass

2062.3602

Monoisotopic_Mass

2061.1433

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 84.19 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Wang J., Xie Y., Luan Y., Guo T., Xiao S., Zeng X., Zhang S.

Title

Identification and dipeptidyl peptidase IV (DPP-IV) inhibitory activity verification of peptides from mouse lymphocytes. Food Sci. Human Wellness, 11, 1515-1526, 2022

Year 2022

Literature Source Journal

Other

Number of Residues 21

Additional Info

BIOPEP database of bioactive peptides SMILES: N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C92H156N24O29/c1-44(2)35-62(84(136)103-51(13)76(128)100-50(12)75(127)99-49(11)74(126)97-40-68(120)105-65(38-55-26-28-56(119)29-27-55)87(139)113-66(39-71(124)125)88(140)116-73(48(9)10)91(143)108-60(30-31-70(122)123)83(135)109-61(92(144)145)25-19-22-34-95)110-79(131)54(16)102-81(133)58(23-17-20-32-93)106-82(134)59(24-18-21-33-94)107-86(138)64(37-46(5)6)111-78(130)53(15)101-77(129)52(14)104-85(137)63(36-45(3)4)112-89(141)67(43-118)114-90(142)72(47(7)8)115-69(121)41-98-80(132)57(96)42-117/h26-29,44-54,57-67,72-73,117-119H,17-25,30-43,93-96H2,1-16H3,(H,97,126)(H,98,132)(H,99,127)(H,100,128)(H,101,129)(H,102,133)(H,103,136)(H,104,137)(H,105,120)(H,106,134)(H,107,138)(H,108,143)(H,109,135)(H,110,131)(H,111,130)(H,112,141)(H,113,139)(H,114,142)(H,115,121)(H,116,140)(H,122,123)(H,124,125)(H,144,145)/t49-,50-,51-,52-,53-,54-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,72-,73-/m0/s1 InChIKey=HNQNRXJBQJPCJO-XEWFNFFKSA-N

Number_of_Residues

21