TPDB

3D PDB MODEL

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TPDB ID TPDB67367

Peptide_Name

Antidiabetic peptide from goat milk αS1-casein f195–204

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

SDIPNPIGSE

FASTA

>TPDB67367|Antidiabetic|length=10
SDIPNPIGSE

Formula C43H69N11O18

Absent Amino Acids ARCQHLKMFTWYV

Common Amino Acids IPS

Mass 1028.08

PI 3.01

Basic Residues 0

Acidic Residues 2

Hydrophobic Residues 2

Net Charge -2

Boman Index 4.22

Hydrophobicity -0.670

Aliphatic Index 78.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

0

A

0

R

1

N

1

D

0

C

1

E

0

Q

1

G

0

H

2

I

0

L

0

K

0

M

0

F

2

P

2

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 2 L: 0 K: 0 M: 0 F: 0 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

10

Formula

C43H69N11O18

Mass

1028.08

PI

3.01

Net Charge

-2

Boman Index

4.22

Hydrophobicity

-0.670

Chemical_Mass

1028.0681

Monoisotopic_Mass

1027.4805

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antidiabetic

Activity Measurement 0.00 µM

Function Ameliorating high-glucose-induced insulin resistance in HepG2 cells

Detail Activity antidiabetic

Activity Code adb

Source & Reference

Database Source NA

Authors Gong H., Gao J., Wang Y., Luo Q.W., Guo K.R., Ren F.Z., Mao X.Y.

Title

Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells. J. Dairy Sci., 103, 4907-4918, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C43H69N11O18/c1-5-20(3)33(40(68)46-17-30(58)47-26(19-56)37(65)48-23(43(71)72)11-12-31(59)60)51-39(67)28-10-7-13-53(28)41(69)25(15-29(45)57)50-38(66)27-9-8-14-54(27)42(70)34(21(4)6-2)52-36(64)24(16-32(61)62)49-35(63)22(44)18-55/h20-28,33-34,55-56H,5-19,44H2,1-4H3,(H2,45,57)(H,46,68)(H,47,58)(H,48,65)(H,49,63)(H,50,66)(H,51,67)(H,52,64)(H,59,60)(H,61,62)(H,71,72)/t20-,21-,22-,23-,24-,25-,26-,27-,28-,33-,34-/m0/s1 InChIKey=UJFVXEAGAUAFIC-DKTSMWQESA-N

Number_of_Residues

10