TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB67363

Peptide_Name

Dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

SAPRHGSLGFLPRK

FASTA

>TPDB67363|Antidiabetic|length=14
SAPRHGSLGFLPRK

Formula C68H111N23O17

Absent Amino Acids NDCEQIMTWYV

Common Amino Acids RGLPS

Mass 1522.77

PI 12.41

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +3

Boman Index 2.33

Hydrophobicity -0.679

Aliphatic Index 62.86

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

2

R

0

N

0

D

0

C

0

E

0

Q

2

G

1

H

0

I

2

L

1

K

0

M

1

F

2

P

2

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 2 K: 1 M: 0 F: 1 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

14

Formula

C68H111N23O17

Mass

1522.77

PI

12.41

Net Charge

+3

Boman Index

2.33

Hydrophobicity

-0.679

Chemical_Mass

1522.7484

Monoisotopic_Mass

1521.8504

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 23.44 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Wang J., Xie Y., Luan Y., Guo T., Xiao S., Zeng X., Zhang S.

Title

Identification and dipeptidyl peptidase IV (DPP-IV) inhibitory activity verification of peptides from mouse lymphocytes. Food Sci. Human Wellness, 11, 1515-1526, 2022

Year 2022

Literature Source Journal

Other

Number of Residues 14

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C68H111N23O17/c1-37(2)27-46(87-61(102)50(35-93)83-54(95)33-79-57(98)48(30-41-31-75-36-80-41)88-59(100)44(19-12-24-77-68(73)74)85-62(103)51-20-13-25-90(51)64(105)39(5)81-55(96)42(70)34-92)56(97)78-32-53(94)82-47(29-40-15-7-6-8-16-40)60(101)89-49(28-38(3)4)65(106)91-26-14-21-52(91)63(104)84-43(18-11-23-76-67(71)72)58(99)86-45(66(107)108)17-9-10-22-69/h6-8,15-16,31,36-39,42-52,92-93H,9-14,17-30,32-35,69-70H2,1-5H3,(H,75,80)(H,78,97)(H,79,98)(H,81,96)(H,82,94)(H,83,95)(H,84,104)(H,85,103)(H,86,99)(H,87,102)(H,88,100)(H,89,101)(H,107,108)(H4,71,72,76)(H4,73,74,77)/t39-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-/m0/s1 InChIKey=AQMSBAVARSXPMX-WAZINIRISA-N

Number_of_Residues

14