TPDB

3D PDB MODEL

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TPDB ID TPDB67315

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

QLRDIVDK

FASTA

>TPDB67315|Antidiabetic|length=8
QLRDIVDK

Formula C42H75N13O14

Absent Amino Acids ANCEGHMFPSTWY

Common Amino Acids D

Mass 986.14

PI 6.90

Basic Residues 2

Acidic Residues 2

Hydrophobic Residues 3

Net Charge -0

Boman Index 4.04

Hydrophobicity -0.800

Aliphatic Index 133.75

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

1

R

0

N

2

D

0

C

0

E

1

Q

0

G

0

H

1

I

1

L

1

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 2 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

8

Formula

C42H75N13O14

Mass

986.14

PI

6.90

Net Charge

-0

Boman Index

4.04

Hydrophobicity

-0.800

Chemical_Mass

986.1206

Monoisotopic_Mass

985.5539

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 8.55 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Majid A., Lakshmikanth M., Lokanath N. K., Poornima Priyadarshini C. G.

Title

Generation, characterization and molecular binding mechanism of novel dipeptidyl peptidase-1003 4 inhibitory peptides from sorghum bicolor seed protein. Food Chem, 369, 130888, 2022

Year 2022

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C42H75N13O14/c1-7-22(6)33(40(67)54-32(21(4)5)39(66)53-27(18-30(57)58)37(64)50-25(41(68)69)11-8-9-15-43)55-38(65)28(19-31(59)60)52-35(62)24(12-10-16-48-42(46)47)49-36(63)26(17-20(2)3)51-34(61)23(44)13-14-29(45)56/h20-28,32-33H,7-19,43-44H2,1-6H3,(H2,45,56)(H,49,63)(H,50,64)(H,51,61)(H,52,62)(H,53,66)(H,54,67)(H,55,65)(H,57,58)(H,59,60)(H,68,69)(H4,46,47,48)/t22-,23-,24-,25-,26-,27-,28-,32-,33-/m0/s1 InChIKey= MIQXFMOJXIFLAF-HFELWZQXSA-N

Number_of_Residues

8