TPDB

3D PDB MODEL

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TPDB ID TPDB67287

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

PPGLPGSPGQ

FASTA

>TPDB67287|Antidiabetic|length=10
PPGLPGSPGQ

Formula C40H63N11O13

Absent Amino Acids ARNDCEHIKMFTWYV

Common Amino Acids P

Mass 906.01

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index 1.98

Hydrophobicity -0.810

Aliphatic Index 39.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

3

G

0

H

0

I

1

L

0

K

0

M

0

F

4

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 4 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

10

Formula

C40H63N11O13

Mass

906.01

PI

6.02

Net Charge

-0

Boman Index

1.98

Hydrophobicity

-0.810

Chemical_Mass

905.9916

Monoisotopic_Mass

905.4592

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 0.55 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Yu Y., Jin Y., Wang F., Yan J., Qi Y., Ye M.

Title

Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion. Food Research International, 96, 182–190, 2017

Year 2017

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C40H63N11O13/c1-22(2)17-25(47-32(55)19-44-34(57)27-8-4-14-49(27)37(60)23-7-3-13-42-23)38(61)50-15-5-9-28(50)35(58)45-20-33(56)48-26(21-52)39(62)51-16-6-10-29(51)36(59)43-18-31(54)46-24(40(63)64)11-12-30(41)53/h22-29,42,52H,3-21H2,1-2H3,(H2,41,53)(H,43,59)(H,44,57)(H,45,58)(H,46,54)(H,47,55)(H,48,56)(H,63,64)/t23-,24-,25-,26-,27-,28-,29-/m0/s1 InChIKey= FIOVNEDFYUCGBJ-BMGWUDNWSA-N

Number_of_Residues

10