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Peptide record

TPDB67273

Dipeptidyl peptidase IV inhibitor Antidiabetic standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB67273
Dipeptidyl peptidase IV inhibitor
Antidiabetic
Cardiometabolic peptides
pep-lab Peptipedia
standard
No
A 7-aa standard natural antidiabetic peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.
Sequence
PGPIHDS
Physicochemical Analysis
C31H47N9O11
ARNCEQLKMFTWYV
P
721.77
4.94
1
1
1
-1
2.92
-0.943
55.71
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
1
H
1
I
0
L
0
K
0
M
0
F
2
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C31H47N9O11
721.77
4.94
-1
2.92
-0.943
721.7567
721.3384
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
1000.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Uenishi H, Kabuki T, Seto Y, Serizawa A, Nakajima H.
Isolation and identification of casein-derived dipeptidyl-pepdiase-4 (DPP-4)-
2012
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C(=O)O)(NC([C@@](NC([C@@](NC([C@]([C@H](CC)C)(NC([C@]1(N(C(CNC([C@]2(NCCC2)[H])=O)=O)CCC1)[H])=O)[H])=O)(Cc1[nH]cnc1)[H])=O)(CC(=O)O)[H])=O)CO InChI=1S/C31H47N9O11/c1-3-16(2)25(39-29(48)22-7-5-9-40(22)23(42)13-34-26(45)18-6-4-8-33-18)30(49)37-19(10-17-12-32-15-35-17)27(46)36-20(11-24(43)44)28(47)38-21(14-41)31(50)51/h12,15-16,18-22,25,33,41H,3-11,13-14H2,1-2H3,(H,32,35)(H,34,45)(H,36,46)(H,37,49)(H,38,47)(H,39,48)(H,43,44)(H,50,51)/t16-,18-,19-,20-,21-,22-,25-/m0/s1 InChIKey: ISXLGNWBLNNFFT-HNJCEHCYSA-N
Additional Detail Fields 1 fields
7