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Peptide record

TPDB67251

Antidiabetic peptide from goat milk αS2-casein f123–130 Antidiabetic standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB67251
Antidiabetic peptide from goat milk αS2-casein f123–130
Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 8-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
NPWDQVKR
Physicochemical Analysis
C46H71N15O13
ACEGHILMFSTY
RNDQKPWV
1042.16
10.09
2
1
2
+1
2.70
-2.150
36.25
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
5500
527.75
2
Residue Composition
number
0
A
1
R
1
N
1
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
8
C46H71N15O13
1042.16
10.09
+1
2.70
-2.150
1042.1458
1041.5340
Evidence Records 1 records
Evidence 1 Activity

Activity

EC50
Antidiabetic
0.00 µM
Ameliorating high-glucose-induced insulin resistance in HepG2 cells
antidiabetic
adb

Source & Reference

NA
Gong H., Gao J., Wang Y., Luo Q.W., Guo K.R., Ren F.Z., Mao X.Y.
Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells. J. Dairy Sci., 103, 4907-4918, 2020
2020
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC2=C[N]([H])C3=CC=CC=C23)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O InChI=1S/C46H71N15O13/c1-23(2)37(43(71)56-28(11-5-6-16-47)38(66)57-30(45(73)74)12-7-17-53-46(51)52)60-39(67)29(14-15-34(49)62)55-41(69)32(21-36(64)65)58-40(68)31(19-24-22-54-27-10-4-3-9-25(24)27)59-42(70)33-13-8-18-61(33)44(72)26(48)20-35(50)63/h3-4,9-10,22-23,26,28-33,37,54H,5-8,11-21,47-48H2,1-2H3,(H2,49,62)(H2,50,63)(H,55,69)(H,56,71)(H,57,66)(H,58,68)(H,59,70)(H,60,67)(H,64,65)(H,73,74)(H4,51,52,53)/t26-,28-,29-,30-,31-,32-,33-,37-/m0/s1 InChIKey=LLUQMONBIKKILX-YHQUTJHBSA-N Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides
Additional Detail Fields 1 fields
8