TPDB

3D PDB MODEL

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TPDB ID TPDB67162

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

LPVYD

FASTA

>TPDB67162|Antidiabetic|length=5
LPVYD

Formula C29H43N5O9

Absent Amino Acids ARNCEQGHIKMFSTW

Common Amino Acids DLPYV

Mass 605.69

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 0.25

Hydrophobicity 0.320

Aliphatic Index 136.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 246.00

Polar Residues 1

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

5

Formula

C29H43N5O9

Mass

605.69

PI

3.10

Net Charge

-1

Boman Index

0.25

Hydrophobicity

0.320

Chemical_Mass

605.6781

Monoisotopic_Mass

605.3050

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 51.36 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors

Harnedy-Rothwell P. A., McLaughlin C. M., O’Keeffe M. B., le Gouic A. v., Allsopp P. J., McSorley E. M., Sharkey S., Whooley J., McGovern B., et al.

Title

Identification and characterisation of peptides from a boarfish (capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity. Food Research International, 131, 108989, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)O InChI=1S/C29H43N5O9/c1-15(2)12-19(30)28(41)34-11-5-6-22(34)26(39)33-24(16(3)4)27(40)31-20(13-17-7-9-18(35)10-8-17)25(38)32-21(29(42)43)14-23(36)37/h7-10,15-16,19-22,24,35H,5-6,11-14,30H2,1-4H3,(H,31,40)(H,32,38)(H,33,39)(H,36,37)(H,42,43)/t19-,20-,21-,22-,24-/m0/s1 InChIKey= VSAHHBFXSMDRRR-YGQNSOCVSA-N

Number_of_Residues

5