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Peptide record

TPDB67153

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antidiabetic standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB67153
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 7-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
LPPLTAD
Physicochemical Analysis
C33H55N7O11
RNCEQGHIKMFSWYV
LP
725.84
3.10
0
1
3
-1
0.98
0.286
125.71
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
0
F
2
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C33H55N7O11
725.84
3.10
-1
0.98
0.286
725.8279
725.3946
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
1.67 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Yu Y., Jin Y., Wang F., Yan J., Qi Y., Ye M.
Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion. Food Research International, 96, 182–190, 2017
2017
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)O InChI=1S/C33H55N7O11/c1-16(2)13-20(34)31(48)40-12-8-10-24(40)32(49)39-11-7-9-23(39)29(46)36-21(14-17(3)4)28(45)38-26(19(6)41)30(47)35-18(5)27(44)37-22(33(50)51)15-25(42)43/h16-24,26,41H,7-15,34H2,1-6H3,(H,35,47)(H,36,46)(H,37,44)(H,38,45)(H,42,43)(H,50,51)/t18-,19+,20-,21-,22-,23-,24-,26-/m0/s1 InChIKey= JCEKYQNTDLOMGZ-VGZRSWHLSA-N
Additional Detail Fields 1 fields
7