TPDB

3D PDB MODEL

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TPDB ID TPDB67152

Peptide_Name

Antidiabetic peptide from Juglans mandshurica Maxim

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

LPLLR

FASTA

>TPDB67152|Antidiabetic|length=5
LPLLR

Formula C29H54N8O6

Absent Amino Acids ANDCEQGHIKMFSTWYV

Common Amino Acids L

Mass 610.80

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index -0.42

Hydrophobicity 1.060

Aliphatic Index 234.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

3

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C29H54N8O6

Mass

610.80

PI

11.05

Net Charge

+1

Boman Index

-0.42

Hydrophobicity

1.060

Chemical_Mass

610.7869

Monoisotopic_Mass

610.4154

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antidiabetic

Activity Measurement 0.00 µM

Function Beneficial effects on IR state of HepG2 cells under high glucose conditions

Detail Activity antidiabetic

Activity Code adb

Source & Reference

Database Source NA

Authors Wang J., Wu T., Fang L., Liu C., Liu X., Li H., Shi J., Li M., Min W.

Title

Anti-diabetic effect by walnut (Juglans mandshurica Maxim.)-derived peptide LPLLR through inhibiting α-glucosidase and α-amylase, and alleviating insulin resistance of hepatic HepG2 cells. J. Funct. Foods, 69, 103944, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C29H54N8O6/c1-16(2)13-19(30)27(41)37-12-8-10-23(37)26(40)36-22(15-18(5)6)25(39)35-21(14-17(3)4)24(38)34-20(28(42)43)9-7-11-33-29(31)32/h16-23H,7-15,30H2,1-6H3,(H,34,38)(H,35,39)(H,36,40)(H,42,43)(H4,31,32,33)/t19-,20-,21-,22-,23-/m0/s1 InChIKey= OAJZRPXPLBASHH-VUBDRERZSA-N Inhibitor of alpha-amylase (EC 3.2.1.1) according to the BIOPEP-UWM database of bioactive peptides (ID 9703) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9705)

Number_of_Residues

5