TPDB

3D PDB MODEL

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TPDB ID TPDB67041

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

IPVDM

FASTA

>TPDB67041|Antidiabetic|length=5
IPVDM

Formula C25H43N5O8S1

Absent Amino Acids ARNCEQGHLKFSTWY

Common Amino Acids DIMPV

Mass 573.71

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 1.21

Hydrophobicity 1.100

Aliphatic Index 136.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

1

I

0

L

0

K

1

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

5

Formula

C25H43N5O8S1

Mass

573.71

PI

3.10

Net Charge

-1

Boman Index

1.21

Hydrophobicity

1.100

Chemical_Mass

573.7020

Monoisotopic_Mass

573.2822

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 21.72 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors

Harnedy-Rothwell P. A., McLaughlin C. M., O’Keeffe M. B., le Gouic A. v., Allsopp P. J., McSorley E. M., Sharkey S., Whooley J., McGovern B., et al.

Title

Identification and characterisation of peptides from a boarfish (capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity. Food Research International, 131, 108989, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCSC)C(=O)O InChI=1S/C25H43N5O8S/c1-6-14(4)19(26)24(36)30-10-7-8-17(30)22(34)29-20(13(2)3)23(35)28-16(12-18(31)32)21(33)27-15(25(37)38)9-11-39-5/h13-17,19-20H,6-12,26H2,1-5H3,(H,27,33)(H,28,35)(H,29,34)(H,31,32)(H,37,38)/t14-,15-,16-,17-,19-,20-/m0/s1 InChIKey= CSHVYOJXINXNCH-BGZMIMFDSA-N

Number_of_Residues

5