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Peptide record

TPDB67039

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antidiabetic standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB67039
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 5-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
IPQVS
Physicochemical Analysis
C24H42N6O8
ARNDCEGHLKMFTWY
QIPSV
542.63
6.02
0
0
2
-0
0.92
0.560
136.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C24H42N6O8
542.63
6.02
-0
0.92
0.560
542.6240
542.3054
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
52.16 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Xu F., Yao Y., Xu X., Wang M., Pan M., Ji S., Wu J., Jiang D., Ju X., Wang L.
Identification and quantification of DPP-IV-inhibitory peptides from hydrolyzed-rapeseed-protein-derived napin with analysis of the interactions between key Residues and protein domains. J Agric Food Chem, 67 (13), 3679–3690, 2019
2019
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)O InChI=1S/C24H42N6O8/c1-5-13(4)18(26)23(36)30-10-6-7-16(30)21(34)27-14(8-9-17(25)32)20(33)29-19(12(2)3)22(35)28-15(11-31)24(37)38/h12-16,18-19,31H,5-11,26H2,1-4H3,(H2,25,32)(H,27,34)(H,28,35)(H,29,33)(H,37,38)/t13-,14-,15-,16-,18-,19-/m0/s1 InChIKey= BABGATBTUPWRCX-USOAJAOKSA-N
Additional Detail Fields 1 fields
5