TPDB

3D PDB MODEL

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TPDB ID TPDB66970

Peptide_Name

DPPIV inhibitor

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GPFPLLV

FASTA

>TPDB66970|Antidiabetic|length=7
GPFPLLV

Formula C38H59N7O8

Absent Amino Acids ARNDCEQHIKMSTWY

Common Amino Acids LP

Mass 741.93

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 4

Net Charge -0

Boman Index -1.27

Hydrophobicity 1.571

Aliphatic Index 152.86

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

2

L

0

K

0

M

1

F

2

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

7

Formula

C38H59N7O8

Mass

741.93

PI

6.02

Net Charge

-0

Boman Index

-1.27

Hydrophobicity

1.571

Chemical_Mass

741.9148

Monoisotopic_Mass

741.4411

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 263.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Theysgeur S., Cudennec B., Deracinois B., Perrin C., Guiller I., Lepoudère A., Flahaut C., Ravallec R.

Title

New bioactive peptides identified from a tilapia byproduct hydrolysate exerting effects on DPP-IV activity and intestinal hormones regulation after canine gastrointestinal simulated digestion. Molecules, 26, 136, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C38H59N7O8/c1-22(2)18-26(33(47)40-27(19-23(3)4)34(48)43-32(24(5)6)38(52)53)41-36(50)30-15-11-17-45(30)37(51)28(20-25-12-8-7-9-13-25)42-35(49)29-14-10-16-44(29)31(46)21-39/h7-9,12-13,22-24,26-30,32H,10-11,14-21,39H2,1-6H3,(H,40,47)(H,41,50)(H,42,49)(H,43,48)(H,52,53)/t26-,27-,28-,29-,30-,32-/m0/s1 InChIKey=RNGAAKZGZWJBDO-RUAREOIKSA-N

Number_of_Residues

7